Lambertus P van den Heuvel Selected Research

Fanconi Syndrome (Syndrome, Fanconi)

1/2016	Altered mTOR signalling in nephropathic cystinosis.
9/2013	Copper deficiency in patients with cystinosis with cysteamine toxicity.
6/2011	Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells.
11/2008	Mitochondrial complex V expression and activity in cystinotic fibroblasts.
6/2008	Urinary protein excretion pattern and renal expression of megalin and cubilin in nephropathic cystinosis.
11/2005	Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells.

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Lambertus P van den Heuvel Research Topics

Disease

17	Cystinosis 11/2021 - 11/2005
6	Fanconi Syndrome (Syndrome, Fanconi) 01/2016 - 11/2005
5	Chronic Kidney Failure (Chronic Renal Failure) 11/2021 - 06/2011
5	Atypical Hemolytic Uremic Syndrome 01/2019 - 08/2012
3	Infections 07/2019 - 12/2014
3	Renal Insufficiency (Renal Failure) 11/2018 - 04/2013
3	Proteinuria 01/2017 - 06/2008
3	Breast Neoplasms (Breast Cancer) 10/2015 - 04/2011
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 12/2020
2	Kidney Diseases (Kidney Disease) 12/2020 - 07/2019
2	Thrombotic Microangiopathies 01/2019 - 01/2018
2	Disease Progression 01/2019 - 10/2015
2	Body Weight (Weight, Body) 09/2017 - 01/2016
1	Fructose Intolerance (Intolerance, Fructose) 01/2022
1	Rare Diseases (Rare Disease) 11/2021
1	HIV Infections (HIV Infection) 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Inflammation (Inflammations) 01/2020
1	Albuminuria 07/2019
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2019
1	Hematologic Diseases (Blood Diseases) 01/2019
1	Myasthenia Gravis 01/2019
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 11/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 09/2018
1	Drug-Related Side Effects and Adverse Reactions 09/2017
1	Thrombosis (Thrombus) 01/2017
1	Edema (Dropsy) 01/2017
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2017
1	Hypercholesterolemia 02/2016
1	Liver Failure 02/2016
1	Starvation 01/2016
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2016
1	Patent Ductus Arteriosus 10/2015
1	Chronic Renal Insufficiency 10/2015
1	Hyperuricemia 10/2013
1	Hypercalciuria 04/2013

Drug/Important Bio-Agent (IBA)

14	Cystine (L-Cystine)IBA 11/2021 - 11/2005
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 06/2008
7	Cysteamine (Mercaptamine)FDA Link 01/2020 - 01/2006
4	Complement System Proteins (Complement)IBA 01/2019 - 08/2012
4	Adenosine Triphosphate (ATP)IBA 06/2011 - 02/2006
3	AlbuminsIBA 07/2019 - 06/2008
2	histidine-rich proteinsIBA 01/2021 - 07/2019
2	DNA (Deoxyribonucleic Acid)IBA 12/2020 - 01/2019
2	EnzymesIBA 01/2020 - 11/2018
2	CreatinineIBA 07/2019 - 01/2016
2	eculizumab FDA Link 01/2019 - 10/2015
2	Complement Factor H (Factor H)IBA 01/2019 - 08/2012
2	CopperIBA 02/2016 - 09/2013
2	Alkaline PhosphataseIBA 02/2016 - 02/2010
2	Low Density Lipoprotein Receptor-Related Protein-2IBA 04/2013 - 06/2008
2	intrinsic factor-cobalamin receptorIBA 04/2013 - 06/2008
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 02/2013 - 04/2011
1	Polysaccharides (Glycans)IBA 01/2022
1	Mannose (D-Mannose)IBA 01/2022
1	Disulfiram (Antabuse)FDA Link 11/2021
1	SymportersIBA 11/2021
1	Apolipoprotein L1IBA 01/2021
1	coenzyme Q10 (CoQ10)IBA 12/2020
1	chitotriosidaseIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Membrane Transport Proteins (Biological Pump)IBA 11/2018
1	Amino Acids FDA Link 11/2018
1	Gentamicins (Gentamicin)FDA LinkGeneric 09/2017
1	AminoglycosidesIBA 09/2017
1	Ceftazidime (Fortum)FDA LinkGeneric 09/2017
1	ReninIBA 09/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2017
1	MorpholinosIBA 01/2017
1	nephrinIBA 01/2017
1	Transaminases (Aminotransferases)IBA 02/2016
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2016
1	Complement C5 (Complement 5)IBA 10/2015
1	GlucuronidesIBA 10/2015
1	Indomethacin (Indometacin)FDA LinkGeneric 10/2015
1	Sulfates (Sulfates, Inorganic)IBA 10/2015
1	Ibuprofen (Motrin)FDA LinkGeneric 10/2015
1	Calcineurin InhibitorsIBA 03/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2014
1	Urate Oxidase (Uricase)IBA 10/2013
1	Uric Acid (Urate)IBA 10/2013
1	KynurenineIBA 10/2013
1	Oxonic AcidIBA 10/2013
1	Tryptophan (L-Tryptophan)FDA Link 10/2013
1	Kynurenic Acid (Kynurenate)IBA 10/2013
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 09/2013
1	Copper Transport ProteinsIBA 09/2013
1	Procollagen Type IIBA 09/2013

Therapy/Procedure

6	Therapeutics 01/2021 - 10/2015
4	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2020 - 01/2011
2	Hematopoietic Stem Cell Transplantation 01/2019 - 11/2018
2	Renal Dialysis (Hemodialysis) 01/2017 - 09/2013
1	Precision Medicine 09/2018
1	Injections 01/2017
1	Liver Transplantation 02/2016
1	Organ Transplantation 03/2015
1	Kidney Transplantation 09/2013